Behandling af hovedpine/migræne

Botox® behandling af hovedpine/migræne

Botox® blev i Juli 2010, godkendt til migænebehandling.Det har dog ikke  vist sig at være effektiv til enhver form for hovedpine type.

Hvad er botulinumtoxin?

Botulisme – paralyse af muskler som følge af høje doser af botulinumtoxin – blev først beskrevet i 1817. Den ansvarlige bakterie, Clostridium botulinum, blev ikke isoleret indtil 1895. Der findes idag syv forskellige undertyper af kendte botulinumtoksiner.

En meget fortyndet forberedelse af botulinumtoksin type A (Botox ®) blev indført i klinisk praksis i 1970′erne og 1980′erne til at behandle knibe og blefarospasme.

Siden da har fundet anvendelse i andre områder, herunder dystoni , post-takts spasticitet også hos børn, og hyperhidrosis (overdreven svedproduktion).

Botulinumtoksin og Hovedpine/migræne

I midten af ​​1990′erne en række mennesker har rapporteret forbedring i hovedpine hos patienter i botulinumtoksin af andre årsager. Velgennemførte kliniske forsøg med botulinustoksin til forskellige typer af hovedpine, viste positive resultater specielt ved spændingshovedpine, episodisk migræne, og udifferentierede kronisk hovedpine.

Hvordan virker det på hovedpine/migræne?

Der er forskellige former for muskelspændinger, disse afhjælpes ved at afslappe de muskelområder der er særligt aktive og giver spændinger.Det er ofte muskler i panden og nakken samt kæbemusklen der er skyld i hovedpinen.Man ved ikke præcis hvorfor behandling med Botox®  hjælper på hovedpine og migræne, men man formoder at det skyldes reduktion af spændinger i de nævnte muskler og Botulinumtoksinen derfor  menes at hæmme frigivelsen af ​​perifere nociceptive neurotransmittere, som derefter kan have en afsmittende effekt på de centrale smerter systemer, der genererer migræne hovedpine. Og derved fjerne eller reducere smerterne i sådan en grad at disse er acceptable.

Er det den rigtige behandling for mig?

Kun patienter med kronisk migræne er berettiget til behandling med Botox®  i offentlig regi. Kronisk migræne defineres som hovedpine, der forekommer på ≥ 15 dage hver måned. Og klargøres ved en grundig udredning på hospitalet. Så er der den kategori af patienter der i forbindelse med kosmetisk behandling, har opdaget at deres hovedpine/migræne er forsvundet og derved føler en enorm lettelse i forbindelse med denne behandling.  Disse patienter fortsætter således deres behandling for at holde symptomer væk.


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